(511) Fast Metabolism of Tacrolimus and Impact of Dosing in Heart Transplant Patients

PurposePatients after Heart Transplant (HT) requires immune suppression with corticosteroids, mycophenolate and tacrolimus. Tacrolimus is an integral part of immunosuppression HT metabolized by the CYP3A5 pathway. There are fast, intermediate slow metabolizers Also, safety tacrolimus in these unknown. We explored utility pharmacogenomics analysis tacrolimus.MethodsThis a retrospective study 20 patients from Jan 2021-Sep 2022. Patients were divided into metabolizer (CYP3A5) (15 patients), (2 patients) fast (3 patients). combined because their similar behavior. Primary outcome was first day therapeutic levels. Secondary outcomes starting dose, dose (mg/kg) days to reach used t-test compare means among 2 groups 95% CI. adjusted for imbalanced characteristics at baseline: age & race.ResultsMean 48 ± 9 years 40% females. no difference age, gender, kidney function presence tremors both groups. showed that (Fast metabolizers: 12 3.1 vs 4.6 1, P<0.01) present. Results explained table graph.ConclusionPatients required 2.5 times higher as compared metabolizers. Majority (80%) African Americans. need larger studies further explore levels This race. Mean graph.